We have developed a new methodology for searching new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by addition of dsDNA. Furthermore, resulting peptide-acridine conjugate showed strong binding to dsDNA. These results indicate that DNA-templated click chemistry is applicable to search new DNA binding peptide-acridine conjugates from random peptide library.
|Number of pages||2|
|Journal||Nucleic acids symposium series (2004)|
|Publication status||Published - 2008 Dec 1|
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