New methodology to search for DNA binding ligands based on duplex DNA-templated click chemistry.

Shuhei Imoto, Tomoya Hirohama, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a new methodology for searching new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by addition of dsDNA. Furthermore, resulting peptide-acridine conjugate showed strong binding to dsDNA. These results indicate that DNA-templated click chemistry is applicable to search new DNA binding peptide-acridine conjugates from random peptide library.

Original languageEnglish
Pages (from-to)381-382
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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