TY - JOUR
T1 - New insights on T-cell self-tolerance
AU - Yi, Jaeu
AU - Kawabe, Takeshi
AU - Sprent, Jonathan
N1 - Funding Information:
This work was supported by National Health and Medical Research Council ( APP1145714 , APP1078243 )
PY - 2020/4
Y1 - 2020/4
N2 - Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naïve cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naïve and MP T cells.
AB - Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naïve cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naïve and MP T cells.
UR - http://www.scopus.com/inward/record.url?scp=85075555877&partnerID=8YFLogxK
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U2 - 10.1016/j.coi.2019.10.002
DO - 10.1016/j.coi.2019.10.002
M3 - Review article
C2 - 31786417
AN - SCOPUS:85075555877
VL - 63
SP - 14
EP - 20
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
ER -