New insights into the functions of enamel matrices in calcified tissues

Satoshi Fukumoto, Takashi Nakamura, Aya Yamada, Makiko Arakaki, Kan Saito, Juan Xu, Emiko Fukumoto, Yoshihiko Yamada

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Ameloblasts secrete enamel matrix proteins, including amelogenin, ameloblastin, enamelin, amelotin, and Apin/odontogenic ameloblast-associated protein (Apin/ODAM). Amelogenin is the major protein component of the enamel matrix. Amelogenin, ameloblastin, and enamelin are expressed during the secretory stage of ameloblast, while amelotin and Apin/ODAM are expressed during the maturation. Amelogenin and ameloblastin are also expressed in osteoblasts, and they regulate bone formation. In addition, recent studies show the importance of protein-protein interactions between enamel matrix components for enamel formation. In a mouse model mimicking a mutation of the amelogenin gene in amelogenesis imperfect (AI) in humans, the mutated amelogenin forms a complex with ameloblastin, which accumulates in the endoplasmic reticulum/Golgi apparatus and causes ameloblast dysfunction resulting in AI phenotypes. Ameloblastin is a cell adhesion molecule that regulates cell proliferation. It inhibits odontogenic tumor formation and regulates osteoblast differentiation through binding to CD63. Amelotin interacts with Apin/ODAM, but not ameloblastin, while Apin/ODAM binds to ameloblastin. These interactions may be important for enamel mineralization during amelogenesis. The enamel matrix genes are clustered on human chromosome 4 except for the amelogenin genes located on the sex chromosomes. Genes for these enamel matrix proteins evolved from a common ancestral gene encoding secretory calcium-binding phosphoprotein.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalJapanese Dental Science Review
Volume50
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • Ameloblastin
  • Amelogenin
  • Amelotin
  • Apin
  • Enamel matrix
  • Enamelin
  • Odontogenic ameloblast-associated protein

ASJC Scopus subject areas

  • Dentistry(all)

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