Abstract
In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.
Original language | English |
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Pages (from-to) | 203-208 |
Number of pages | 6 |
Journal | Brain Tumor Pathology |
Volume | 28 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2011 Jul |
Keywords
- Astrocytoma
- Glioblastoma
- IDH1
- Oligodendroglioma
- Pilocytic astrocytoma
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
- Cancer Research