New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara; Yukihiko Sonoda; Masayuki Kanamori; Ryuta Saito; Toshihiro Kumabe; Teiji Tominaga

doi:10.1007/s10014-011-0050-4

New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara, Yukihiko Sonoda, Masayuki Kanamori, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

Original language	English
Pages (from-to)	203-208
Number of pages	6
Journal	Brain Tumor Pathology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1007/s10014-011-0050-4
Publication status	Published - 2011 Jul

Keywords

Astrocytoma
Glioblastoma
IDH1
Oligodendroglioma
Pilocytic astrocytoma

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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title = "New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status",

abstract = "In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.",

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author = "Ichiyo Shibahara and Yukihiko Sonoda and Masayuki Kanamori and Ryuta Saito and Toshihiro Kumabe and Teiji Tominaga",

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AU - Shibahara, Ichiyo

AU - Sonoda, Yukihiko

AU - Kanamori, Masayuki

AU - Saito, Ryuta

AU - Kumabe, Toshihiro

AU - Tominaga, Teiji

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AB - In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

KW - Astrocytoma

KW - Glioblastoma

KW - IDH1

KW - Oligodendroglioma

KW - Pilocytic astrocytoma

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