New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara; Yukihiko Sonoda; Masayuki Kanamori; Ryuta Saito; Toshihiro Kumabe; Teiji Tominaga

doi:10.1007/s10014-011-0050-4

New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara, Yukihiko Sonoda, Masayuki Kanamori, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

MED - Medical Sciences

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

Original language	English
Pages (from-to)	203-208
Number of pages	6
Journal	Brain Tumor Pathology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1007/s10014-011-0050-4
Publication status	Published - 2011 Jul 1

Keywords

Astrocytoma
Glioblastoma
IDH1
Oligodendroglioma
Pilocytic astrocytoma

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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10.1007/s10014-011-0050-4

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Shibahara, I., Sonoda, Y., Kanamori, M., Saito, R., Kumabe, T., & Tominaga, T. (2011). New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status. Brain Tumor Pathology, 28(3), 203-208. https://doi.org/10.1007/s10014-011-0050-4

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abstract = "In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.",

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