New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara, Yukihiko Sonoda, Masayuki Kanamori, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalBrain Tumor Pathology
Volume28
Issue number3
DOIs
Publication statusPublished - 2011 Jul 1

Keywords

  • Astrocytoma
  • Glioblastoma
  • IDH1
  • Oligodendroglioma
  • Pilocytic astrocytoma

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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