New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara; Yukihiko Sonoda; Masayuki Kanamori; Ryuta Saito; Toshihiro Kumabe; Teiji Tominaga

doi:10.1007/s10014-011-0050-4

New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Ichiyo Shibahara, Yukihiko Sonoda, Masayuki Kanamori, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

Original language	English
Pages (from-to)	203-208
Number of pages	6
Journal	Brain Tumor Pathology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1007/s10014-011-0050-4
Publication status	Published - 2011 Jul

Keywords

Astrocytoma
Glioblastoma
IDH1
Oligodendroglioma
Pilocytic astrocytoma

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10014-011-0050-4

Cite this

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title = "New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status",

abstract = "In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.",

keywords = "Astrocytoma, Glioblastoma, IDH1, Oligodendroglioma, Pilocytic astrocytoma",

author = "Ichiyo Shibahara and Yukihiko Sonoda and Masayuki Kanamori and Ryuta Saito and Toshihiro Kumabe and Teiji Tominaga",

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T1 - New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

AU - Shibahara, Ichiyo

AU - Sonoda, Yukihiko

AU - Kanamori, Masayuki

AU - Saito, Ryuta

AU - Kumabe, Toshihiro

AU - Tominaga, Teiji

PY - 2011/7

Y1 - 2011/7

N2 - In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

AB - In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

KW - Astrocytoma

KW - Glioblastoma

KW - IDH1

KW - Oligodendroglioma

KW - Pilocytic astrocytoma

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New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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