New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

Osamu Yoshida, Jun Nakamura, Hidenori Yamashiro, Kenji Miura, Sayaka Hayashi, Kosei Umetsu, Shu Xu, Hideki Maki, Hirokazu Arimoto

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.

    Original languageEnglish
    Pages (from-to)278-282
    Number of pages5
    JournalMedChemComm
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - 2011 Apr

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis'. Together they form a unique fingerprint.

    Cite this