New inhibitors for expression of IgE receptor on human mast cell

Satoru Tamura, Kunichika Yoshihira, Katsuaki Fujiwara, Nobutoshi Murakami

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Exploration for inhibitors against expression of IgE receptor (FcεRI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epicatechin gallate, and gallocatechin gallate as active principles. Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of FcεRI. Structure-activity relationship analysis among catechins, anthocyanidins, and flavones revealed the pyrogallol moiety to be crucial for biological potency. Furthermore, EGCG was clarified to reduce generation of γ-chain subunit to suppress expression of FcεRI on human mast cells.

Original languageEnglish
Pages (from-to)2299-2302
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number7
DOIs
Publication statusPublished - 2010 Apr 1

Keywords

  • Anti-allergy
  • Delphinidin
  • Epigallocatechin gallate
  • FcεRI
  • Human mast cell
  • Tricetinidin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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