New galactosyllactose containing α-glycosidic linkage isolated from ovine (Booroola dorset) colostrum

Tadasu Urashima; Tadao Saito; Junko Nishimura; Hideko Ariga

doi:10.1016/0304-4165(89)90099-8

New galactosyllactose containing α-glycosidic linkage isolated from ovine (Booroola dorset) colostrum

Tadasu Urashima, Tadao Saito, Junko Nishimura, Hideko Ariga

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Three trisaccharides, tetra-, penta-, hexa- and certain higher oligosaccharides were obtained from ovine colostrum as free forms. The chemical structure of the three trisaccharides were determined by methylation and ¹³C-NMR analyses to be as follows: Galα13Galβ14Glc, Galβ13Galβ14Glc (3′-galactosyllactose) and Galβ16Galβ14Glc (6′-galactosyllactose). Galα13Galβ14Glc, which had been confirmed as the oligosaccharide portion of a glycolipid prepared biosynthetically from rat spleen or bone marrow, has been identified for the first time from natural sources as a free form. The trisaccharide containing α-galactosyl unit is a novel compound in mammalian milk.

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	BBA - General Subjects
Volume	992
Issue number	3
DOIs	https://doi.org/10.1016/0304-4165(89)90099-8
Publication status	Published - 1989 Sep 15

Keywords

(Ovine colostrum)
C-
Carbohydrate structure
Galactosyllactose
NMR
Oligosaccharide
neutral

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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title = "New galactosyllactose containing α-glycosidic linkage isolated from ovine (Booroola dorset) colostrum",

abstract = "Three trisaccharides, tetra-, penta-, hexa- and certain higher oligosaccharides were obtained from ovine colostrum as free forms. The chemical structure of the three trisaccharides were determined by methylation and 13C-NMR analyses to be as follows: Galα13Galβ14Glc, Galβ13Galβ14Glc (3′-galactosyllactose) and Galβ16Galβ14Glc (6′-galactosyllactose). Galα13Galβ14Glc, which had been confirmed as the oligosaccharide portion of a glycolipid prepared biosynthetically from rat spleen or bone marrow, has been identified for the first time from natural sources as a free form. The trisaccharide containing α-galactosyl unit is a novel compound in mammalian milk.",

keywords = "(Ovine colostrum), C-, Carbohydrate structure, Galactosyllactose, NMR, Oligosaccharide, neutral",

author = "Tadasu Urashima and Tadao Saito and Junko Nishimura and Hideko Ariga",

year = "1989",

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T1 - New galactosyllactose containing α-glycosidic linkage isolated from ovine (Booroola dorset) colostrum

AU - Urashima, Tadasu

AU - Saito, Tadao

AU - Nishimura, Junko

AU - Ariga, Hideko

PY - 1989/9/15

Y1 - 1989/9/15

N2 - Three trisaccharides, tetra-, penta-, hexa- and certain higher oligosaccharides were obtained from ovine colostrum as free forms. The chemical structure of the three trisaccharides were determined by methylation and 13C-NMR analyses to be as follows: Galα13Galβ14Glc, Galβ13Galβ14Glc (3′-galactosyllactose) and Galβ16Galβ14Glc (6′-galactosyllactose). Galα13Galβ14Glc, which had been confirmed as the oligosaccharide portion of a glycolipid prepared biosynthetically from rat spleen or bone marrow, has been identified for the first time from natural sources as a free form. The trisaccharide containing α-galactosyl unit is a novel compound in mammalian milk.

AB - Three trisaccharides, tetra-, penta-, hexa- and certain higher oligosaccharides were obtained from ovine colostrum as free forms. The chemical structure of the three trisaccharides were determined by methylation and 13C-NMR analyses to be as follows: Galα13Galβ14Glc, Galβ13Galβ14Glc (3′-galactosyllactose) and Galβ16Galβ14Glc (6′-galactosyllactose). Galα13Galβ14Glc, which had been confirmed as the oligosaccharide portion of a glycolipid prepared biosynthetically from rat spleen or bone marrow, has been identified for the first time from natural sources as a free form. The trisaccharide containing α-galactosyl unit is a novel compound in mammalian milk.

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KW - Carbohydrate structure

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KW - NMR

KW - Oligosaccharide

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