New frontiers in gut nutrient sensor research: Free fatty acid sensing in the gastrointestinal tract

Satoshi Miyauchi, Akira Hirasawa, Atsuhiko Ichimura, Takafumi Hara, Gozoh Tsujimoto

Research output: Contribution to journalShort surveypeer-review

55 Citations (Scopus)

Abstract

Utilizing the human genome database, the recently developed G-protein-coupled receptors (GPCRs) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs). FFAs have been demonstrated to act as ligands of several GPCRs (FFAR1, FFAR2, FFAR3, and GPR120). These fatty acid receptors are proposed to play critical roles in various types of physiological homeostases. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. It has been elucidated that these four receptors are expressed in the gastrointestinal tract and have many essential roles as sensors of FFA. In this review, we summarize the physiological and pharmacological function of the receptors in the gastrointestinal tract.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalJournal of Pharmacological Sciences
Volume112
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • FFAR2
  • FFAR3
  • Free fatty acid
  • Free fatty acid receptor (FFAR) 1
  • GPR120
  • Gastrointestinal tract

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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