TY - JOUR
T1 - New frontiers in gut nutrient sensor research
T2 - Free fatty acid sensing in the gastrointestinal tract
AU - Miyauchi, Satoshi
AU - Hirasawa, Akira
AU - Ichimura, Atsuhiko
AU - Hara, Takafumi
AU - Tsujimoto, Gozoh
PY - 2010
Y1 - 2010
N2 - Utilizing the human genome database, the recently developed G-protein-coupled receptors (GPCRs) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs). FFAs have been demonstrated to act as ligands of several GPCRs (FFAR1, FFAR2, FFAR3, and GPR120). These fatty acid receptors are proposed to play critical roles in various types of physiological homeostases. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. It has been elucidated that these four receptors are expressed in the gastrointestinal tract and have many essential roles as sensors of FFA. In this review, we summarize the physiological and pharmacological function of the receptors in the gastrointestinal tract.
AB - Utilizing the human genome database, the recently developed G-protein-coupled receptors (GPCRs) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs). FFAs have been demonstrated to act as ligands of several GPCRs (FFAR1, FFAR2, FFAR3, and GPR120). These fatty acid receptors are proposed to play critical roles in various types of physiological homeostases. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. It has been elucidated that these four receptors are expressed in the gastrointestinal tract and have many essential roles as sensors of FFA. In this review, we summarize the physiological and pharmacological function of the receptors in the gastrointestinal tract.
KW - FFAR2
KW - FFAR3
KW - Free fatty acid
KW - Free fatty acid receptor (FFAR) 1
KW - GPR120
KW - Gastrointestinal tract
UR - http://www.scopus.com/inward/record.url?scp=75749092632&partnerID=8YFLogxK
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U2 - 10.1254/jphs.09R09FM
DO - 10.1254/jphs.09R09FM
M3 - Short survey
C2 - 20093784
AN - SCOPUS:75749092632
VL - 112
SP - 19
EP - 24
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8648
IS - 1
ER -