New dimeric and monomeric chromanones, gonytolides D-G, isolated from the fungus Gonytrichum sp.

Haruhisa Kikuchi, Masato Isobe, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In the course of the screening of innate immune regulators from natural resources, we isolated new dimeric and monomeric chromanones, gonytolides D-G (4-7), from Gonytrichum sp. along with a known innate immune promoter, gonytolide A (1). The structures of these compounds were determined by spectral analysis, chemical conversion, and biogenetic consideration. The compounds 4-7 were evaluated on the innate immune response, indicating that the 8,8′-linked bischromanone rings were crucial for innate immune-promoting activity.

Original languageEnglish
Pages (from-to)6218-6223
Number of pages6
JournalTetrahedron
Volume68
Issue number31
DOIs
Publication statusPublished - 2012 Aug 5

Keywords

  • Bischromanone
  • Gonytrichum sp.
  • Innate immunity
  • Tetrahydroxanthone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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