New aureothin derivative, alloaureothin, from Streptomyces sp. MM23

Jun Ya Ueda, Junko Hashimoto, Aya Nagai, Takuji Nakashima, Hisayuki Komaki, Kozue Anzai, Shigeaki Harayama, Takayuki Doi, Takashi Takahashi, Kazuo Nagasawa, Tohru Natsume, Motoki Takagi, Kazuo Shin-ya

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A new polypropionate alloaureothin (1) possessing a nitro group, together with a known polypropionate aureothin (2), was isolated from mycelium of Streptomyces sp. MM23. The structure was determined on the basis of spectroscopic data. 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 30 μM.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number5
DOIs
Publication statusPublished - 2007 May

Keywords

  • Alloaureothin
  • Cytotoxic
  • Polypropionate
  • Streptomyces sp.

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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