New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose

H. Okamoto, S. Takasawa, A. Tohgo

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated β-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalBiochimie
Volume77
Issue number5
DOIs
Publication statusPublished - 1995

Keywords

  • ADP-ribosyl cyclase
  • CD38
  • cyclic ADP-ribose hydrolase
  • insulin

ASJC Scopus subject areas

  • Biochemistry

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