New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

Katsuhiko Nishimori, Yuki Takayanagi, Masahide Yoshida, Yoshiyuki Kasahara, Larry J. Young, Masaki Kawamata

Research output: Chapter in Book/Report/Conference proceedingChapter

63 Citations (Scopus)

Abstract

To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.

Original languageEnglish
Title of host publicationAdvances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease
EditorsInga Neumann, Rainer Landgraf
Pages79-90
Number of pages12
DOIs
Publication statusPublished - 2008 Jul 24

Publication series

NameProgress in Brain Research
Volume170
ISSN (Print)0079-6123

Keywords

  • aggressive behaviours
  • localization of oxytocin receptor expressing neurons
  • maternal behaviours
  • social discrimination
  • thermo regulation

ASJC Scopus subject areas

  • Neuroscience(all)

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    Nishimori, K., Takayanagi, Y., Yoshida, M., Kasahara, Y., Young, L. J., & Kawamata, M. (2008). New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance. In I. Neumann, & R. Landgraf (Eds.), Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease (pp. 79-90). (Progress in Brain Research; Vol. 170). https://doi.org/10.1016/S0079-6123(08)00408-1