New approach to the progesterone BCD-ring system by utilizing a tandem transannular radical cyclization

Satoshi Tomida, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The synthesis of the progesterone BCD-ring system utilizing a tandem transannular radical cyclization and its diastereoselectivity based on MM2 transition state model calculations (flexible model) are described.

Original languageEnglish
Pages (from-to)2363-2366
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number12
DOIs
Publication statusPublished - 1999 Mar 19
Externally publishedYes

Keywords

  • Molecular modelling/mechanics
  • Radicals and radical reactions
  • Steroids and sterols
  • Transannular reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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