New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

Satoru Tamura, Bruno Kilunga Kubata, Syamsurizal, Sawako Itagaki, Toshihiro Horii, Muzele Kalulu Taba, Nobutoshi Murakami

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation.

Original languageEnglish
Pages (from-to)1520-1523
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number5
DOIs
Publication statusPublished - 2010 Mar 1

Keywords

  • African medicinal plant
  • Anti-malarial
  • Iridoid
  • Morinda morindoides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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