New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium

Nobutoshi Murakami; Huq Mohammad Mostaqul; Satoru Tamura; Sawako Itagaki; Toshihiro Horii; Motomasa Kobayashi

doi:10.1016/S0960-894X(01)00467-X

New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium

Nobutoshi Murakami, Huq Mohammad Mostaqul, Satoru Tamura, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

SCI - Chemistry

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.

Original language	English
Pages (from-to)	2445-2447
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(01)00467-X
Publication status	Published - 2001 Sep 17

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.",

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AU - Murakami, Nobutoshi

AU - Mostaqul, Huq Mohammad

AU - Tamura, Satoru

AU - Itagaki, Sawako

AU - Horii, Toshihiro

AU - Kobayashi, Motomasa

PY - 2001/9/17

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AB - Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.

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