TY - JOUR
T1 - New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium
AU - Murakami, Nobutoshi
AU - Mostaqul, Huq Mohammad
AU - Tamura, Satoru
AU - Itagaki, Sawako
AU - Horii, Toshihiro
AU - Kobayashi, Motomasa
N1 - Funding Information:
The authors are grateful to the Kanae Foundation for Life and Socio-medical Science for financial support. This research is also financially supported by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture of Japan.
PY - 2001/9/17
Y1 - 2001/9/17
N2 - Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.
AB - Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.
UR - http://www.scopus.com/inward/record.url?scp=0035903924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035903924&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)00467-X
DO - 10.1016/S0960-894X(01)00467-X
M3 - Article
C2 - 11549443
AN - SCOPUS:0035903924
VL - 11
SP - 2445
EP - 2447
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 18
ER -