New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium

Nobutoshi Murakami, Huq Mohammad Mostaqul, Satoru Tamura, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.

Original languageEnglish
Pages (from-to)2445-2447
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number18
DOIs
Publication statusPublished - 2001 Sep 17

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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