Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1

Mehryar Habibi Roudkenar, Raheleh Halabian, Parisa Bahmani, Amaneh Mohammadi Roushandeh, Yoshikazu Kuwahara, Manabu Fukumoto

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Neutrophil Gelatinase-Associated Lipocalin (NGAL/Lcn2), a member of the lipocalin family, has a variety of functions. There are extensive studies examining the expression of NGAL under harmful conditions. However, its precise function remains poorly understood. Heme Oxygenase 1 (HO-1) is an enzyme with well-established cytoprotective effects. Previous work showed that NGAL induces expression of HO-1. Interestingly, the same stimuli induced the expression of both NGAL and HO-1. The current study was designed to (1) determine whether NGAL exerts its cytoprotective effect through HO-1 and (2) compare NGAL and HO-1 with each other in terms of their protective role against oxidative stress. The current data indicate that NGAL exerts its cytoprotective effect independent of HO-1 and protects cells against oxidative stress more efficiently than HO-1. The data also strongly suggest that induction of NGAL under harmful conditions is a compensatory response to ameliorate oxidative stress-mediated toxicity. These findings may suggest new applications of NGAL, particularly when oxidative stress is a major factor.

Original languageEnglish
Pages (from-to)810-819
Number of pages10
JournalFree Radical Research
Volume45
Issue number7
DOIs
Publication statusPublished - 2011 Jul

Keywords

  • HO-1
  • NGAL
  • antioxidant
  • oxidative stress

ASJC Scopus subject areas

  • Biochemistry

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