Neutrophil dysfunction in rats with natural gingivitis

Emiko Isogai; Hitomi Wakizaka; Hiroko Miura; Hiroshi Isogai; Masanobu Hayashi

doi:10.1016/0003-9969(93)90158-I

Neutrophil dysfunction in rats with natural gingivitis

Emiko Isogai, Hitomi Wakizaka, Hiroko Miura, Hiroshi Isogai, Masanobu Hayashi

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The functions of polymorphonuclear neutrophils (PMN) from SUS rats with naturally occurring gingivitis were examined by the luminol-dependent chemiluminescence (CL), adherence and bactericidal tests. SUS rats with pre-gingivitis showed lower CL responses of isolated PMNs and whole blood than control rats (RES rats). After plague formation and progression of gingivitis, the CL response gradually increased in SUS rats. RES rats had healthy gingiva and showed no increase in CL responses. Impaired PMN adherence was observed in SUS rats with pre-gingivitis but not in RES rats. PMNs from SUS rats with pre-gingivitis also showed lower bactericidal activity than those from RES rats. Dysfunction of PMNs might induce gingivitis as a result of decreased protection against periodontal pathogens and an elevated level of CL response can be recognized with progression of gingivitis.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Archives of Oral Biology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/0003-9969(93)90158-I
Publication status	Published - 1993 Jan

Keywords

bacteriocide
gingivitis
neutrophils

ASJC Scopus subject areas

Otorhinolaryngology
Dentistry(all)
Cell Biology

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10.1016/0003-9969(93)90158-I

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title = "Neutrophil dysfunction in rats with natural gingivitis",

abstract = "The functions of polymorphonuclear neutrophils (PMN) from SUS rats with naturally occurring gingivitis were examined by the luminol-dependent chemiluminescence (CL), adherence and bactericidal tests. SUS rats with pre-gingivitis showed lower CL responses of isolated PMNs and whole blood than control rats (RES rats). After plague formation and progression of gingivitis, the CL response gradually increased in SUS rats. RES rats had healthy gingiva and showed no increase in CL responses. Impaired PMN adherence was observed in SUS rats with pre-gingivitis but not in RES rats. PMNs from SUS rats with pre-gingivitis also showed lower bactericidal activity than those from RES rats. Dysfunction of PMNs might induce gingivitis as a result of decreased protection against periodontal pathogens and an elevated level of CL response can be recognized with progression of gingivitis.",

keywords = "bacteriocide, gingivitis, neutrophils",

author = "Emiko Isogai and Hitomi Wakizaka and Hiroko Miura and Hiroshi Isogai and Masanobu Hayashi",

note = "Funding Information: Acknowledgement-This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.",

year = "1993",

month = jan,

doi = "10.1016/0003-9969(93)90158-I",

language = "English",

volume = "38",

pages = "75--78",

journal = "Archives of Oral Biology",

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T1 - Neutrophil dysfunction in rats with natural gingivitis

AU - Isogai, Emiko

AU - Wakizaka, Hitomi

AU - Miura, Hiroko

AU - Isogai, Hiroshi

AU - Hayashi, Masanobu

N1 - Funding Information: Acknowledgement-This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

PY - 1993/1

Y1 - 1993/1

N2 - The functions of polymorphonuclear neutrophils (PMN) from SUS rats with naturally occurring gingivitis were examined by the luminol-dependent chemiluminescence (CL), adherence and bactericidal tests. SUS rats with pre-gingivitis showed lower CL responses of isolated PMNs and whole blood than control rats (RES rats). After plague formation and progression of gingivitis, the CL response gradually increased in SUS rats. RES rats had healthy gingiva and showed no increase in CL responses. Impaired PMN adherence was observed in SUS rats with pre-gingivitis but not in RES rats. PMNs from SUS rats with pre-gingivitis also showed lower bactericidal activity than those from RES rats. Dysfunction of PMNs might induce gingivitis as a result of decreased protection against periodontal pathogens and an elevated level of CL response can be recognized with progression of gingivitis.

AB - The functions of polymorphonuclear neutrophils (PMN) from SUS rats with naturally occurring gingivitis were examined by the luminol-dependent chemiluminescence (CL), adherence and bactericidal tests. SUS rats with pre-gingivitis showed lower CL responses of isolated PMNs and whole blood than control rats (RES rats). After plague formation and progression of gingivitis, the CL response gradually increased in SUS rats. RES rats had healthy gingiva and showed no increase in CL responses. Impaired PMN adherence was observed in SUS rats with pre-gingivitis but not in RES rats. PMNs from SUS rats with pre-gingivitis also showed lower bactericidal activity than those from RES rats. Dysfunction of PMNs might induce gingivitis as a result of decreased protection against periodontal pathogens and an elevated level of CL response can be recognized with progression of gingivitis.

KW - bacteriocide

KW - gingivitis

KW - neutrophils

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U2 - 10.1016/0003-9969(93)90158-I

DO - 10.1016/0003-9969(93)90158-I

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VL - 38

SP - 75

EP - 78

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 1

ER -

Neutrophil dysfunction in rats with natural gingivitis

Abstract

Keywords

ASJC Scopus subject areas

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