Neutral theory in cancer cell population genetics

Atsushi Niida, Watal M. Iwasaki, Hideki Innan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Kimura's neutral theory provides the whole theoretical basis of the behavior of mutations in a Wright-Fisher population. We here discuss how it can be applied to a cancer cell population, in which there is an increasing interest in genetic variation within a tumor. We explain a couple of fundamental differences between cancer cell populations and asexual organismal populations. Once these differences are taken into account, a number of powerful theoretical tools developed for a Wright-Fisher population could be readily contribute to our deeper understanding of the evolutionary dynamics of cancer cell population.

Original languageEnglish
Pages (from-to)1316-1321
Number of pages6
JournalMolecular biology and evolution
Volume35
Issue number6
DOIs
Publication statusPublished - 2018 Jun
Externally publishedYes

Keywords

  • Cancer
  • Neutral theory
  • Selection

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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