Neurovascular uncoupling under mild hypoxic hypoxia: An EEG-fMRI study in rats

Akira Sumiyoshi, Hideaki Suzuki, Hiroaki Shimokawa, Ryuta Kawashima

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation83.6±12.1%) induced significant reductions in fMRI responses (P0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.

Original languageEnglish
Pages (from-to)1853-1858
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number10
Publication statusPublished - 2012 Oct


  • EEG-fMRI
  • baseline physiology
  • messenger molecules
  • neurovascular coupling
  • oxygen availability
  • vasodilation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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