Abstract
The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation83.6±12.1%) induced significant reductions in fMRI responses (P0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.
Original language | English |
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Pages (from-to) | 1853-1858 |
Number of pages | 6 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 32 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2012 Oct |
Keywords
- EEG-fMRI
- baseline physiology
- messenger molecules
- neurovascular coupling
- oxygen availability
- vasodilation
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine