Neurovascular uncoupling under mild hypoxic hypoxia: An EEG-fMRI study in rats

Akira Sumiyoshi; Hideaki Suzuki; Hiroaki Shimokawa; Ryuta Kawashima

doi:10.1038/jcbfm.2012.111

Neurovascular uncoupling under mild hypoxic hypoxia: An EEG-fMRI study in rats

Akira Sumiyoshi, Hideaki Suzuki, Hiroaki Shimokawa, Ryuta Kawashima

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation83.6±12.1%) induced significant reductions in fMRI responses (P0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.

Original language	English
Pages (from-to)	1853-1858
Number of pages	6
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	32
Issue number	10
DOIs	https://doi.org/10.1038/jcbfm.2012.111
Publication status	Published - 2012 Oct

Keywords

EEG-fMRI
baseline physiology
messenger molecules
neurovascular coupling
oxygen availability
vasodilation

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2012.111

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abstract = "The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation83.6±12.1%) induced significant reductions in fMRI responses (P0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.",

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AU - Shimokawa, Hiroaki

AU - Kawashima, Ryuta

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Neurovascular uncoupling under mild hypoxic hypoxia: An EEG-fMRI study in rats

Abstract

Keywords

ASJC Scopus subject areas

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