Neurosarcoidosis manifesting as tremor of the extremities and severe hypopituitarism - Case report

Yoshikazu Ogawa, Teiji Tominaga, Hidetoshi Ikeda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A 48-year-old woman initially presented with significant tremor of the extremities and subsequent severe hypopituitarism. Magnetic resonance imaging showed hyperintense areas in bilateral caudate heads and putamina, and a pituitary mass. L-dopa and corticosteroid were given and the tremor was reduced. Serum markers including autoimmune diseases were negative. Computed tomography and positron emission tomography detected no abnormalities except for pituitary lesion. Transsphenoidal biopsy revealed a noncaseating granuloma including giant cells with destroyed pituitary gland. The diagnosis was sarcoidosis. Diagnosis of isolated neurosarcoidosis is definitely difficult. Biopsy may be essential to establish the diagnosis in such a case. Corticosteroid administration is strongly recommended to avoid irreversible damage to the normal tissues even if histological confirmation was not achieved.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalNeurologia medico-chirurgica
Issue number7
Publication statusPublished - 2008


  • Basal ganglia
  • Hypopituitarism
  • Neurosarcoidosis
  • Tremor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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