TY - JOUR
T1 - Neuropsychosocial features of very mild Alzheimer's disease (CDR 0.5) and progression to dementia in a community
T2 - The tajiri project
AU - Meguro, Kenichi
AU - Shimada, Masumi
AU - Yamaguchi, Satoshi
AU - Sano, Iwao
AU - Inagaki, Hiroki
AU - Matsushita, Masaaki
AU - Sekita, Yasuyoshi
AU - Mori, Etsuro
PY - 2004/12
Y1 - 2004/12
N2 - The borderline condition between normal aging and dementia should be detected to predict further deterioration. The authors cross-sectionally analyzed neuropsychological data, memory complaints, and social activities for community-dwelling older adults. The rate of decline from Clinical Dementia Rating (CDR) 0.5 to dementia during a 3-year interval was also analyzed. Short-term memory rather than long-term memory was found to be sensitive in distinguishing those with CDR O from those with CDR 0.5. Relatives' observations of memory decline rather than subjective memory complaints were significantly different. Participants with CDR 0.5 reported fewer problems with social activities than did their relatives. Ten of the 29 CDR 0.5 participants (34.5%) showed cognitive decline, the decliners showing lower scores on short-term memory and orientation at the baseline condition. The neuropsychological data showed CDR 0.5 to be similar to very mild Alzheimer's disease. It would be better if subjective complaints were excluded from the criteria of the borderline condition.
AB - The borderline condition between normal aging and dementia should be detected to predict further deterioration. The authors cross-sectionally analyzed neuropsychological data, memory complaints, and social activities for community-dwelling older adults. The rate of decline from Clinical Dementia Rating (CDR) 0.5 to dementia during a 3-year interval was also analyzed. Short-term memory rather than long-term memory was found to be sensitive in distinguishing those with CDR O from those with CDR 0.5. Relatives' observations of memory decline rather than subjective memory complaints were significantly different. Participants with CDR 0.5 reported fewer problems with social activities than did their relatives. Ten of the 29 CDR 0.5 participants (34.5%) showed cognitive decline, the decliners showing lower scores on short-term memory and orientation at the baseline condition. The neuropsychological data showed CDR 0.5 to be similar to very mild Alzheimer's disease. It would be better if subjective complaints were excluded from the criteria of the borderline condition.
KW - Alzheimer's disease
KW - Clinical Dementia Rating 0.5
KW - Cognitive Abilities Screening Instrument
KW - Community-based study
UR - http://www.scopus.com/inward/record.url?scp=16644387263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16644387263&partnerID=8YFLogxK
U2 - 10.1177/0891988704269812
DO - 10.1177/0891988704269812
M3 - Article
C2 - 15533988
AN - SCOPUS:16644387263
VL - 17
SP - 183
EP - 189
JO - Journal of Geriatric Psychiatry and Neurology
JF - Journal of Geriatric Psychiatry and Neurology
SN - 0891-9887
IS - 4
ER -