Neuropsychosocial features of very mild Alzheimer's disease (CDR 0.5) and progression to dementia in a community: The tajiri project

Kenichi Meguro, Masumi Shimada, Satoshi Yamaguchi, Iwao Sano, Hiroki Inagaki, Masaaki Matsushita, Yasuyoshi Sekita, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The borderline condition between normal aging and dementia should be detected to predict further deterioration. The authors cross-sectionally analyzed neuropsychological data, memory complaints, and social activities for community-dwelling older adults. The rate of decline from Clinical Dementia Rating (CDR) 0.5 to dementia during a 3-year interval was also analyzed. Short-term memory rather than long-term memory was found to be sensitive in distinguishing those with CDR O from those with CDR 0.5. Relatives' observations of memory decline rather than subjective memory complaints were significantly different. Participants with CDR 0.5 reported fewer problems with social activities than did their relatives. Ten of the 29 CDR 0.5 participants (34.5%) showed cognitive decline, the decliners showing lower scores on short-term memory and orientation at the baseline condition. The neuropsychological data showed CDR 0.5 to be similar to very mild Alzheimer's disease. It would be better if subjective complaints were excluded from the criteria of the borderline condition.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalJournal of Geriatric Psychiatry and Neurology
Issue number4
Publication statusPublished - 2004 Dec


  • Alzheimer's disease
  • Clinical Dementia Rating 0.5
  • Cognitive Abilities Screening Instrument
  • Community-based study

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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