Neuroprotective role of neurotrophins: Relationship between nerve growth factor and apoptotic cell survival pathway after cerebral ischemia

Atsushi Saito, Teiji Tominaga, Pak H. Chan

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Neurotrophins provide a neuroprotective effect in a variety of brain diseases. Recent reports demonstrate that neurotrophins play an important role in the regulation of apoptotic neuronal cell death and in the relationship between this machinery and activation of cell survival pathways. The cascade reactions of the two major cell survival pathways, mitogen-activated protein kinase and phosphatidylinositol 3-kinase, are known to play a critical role in the regulation of apoptotic neuronal cell survival pathways. Neurotrophins such as nerve growth factor regulate these two cell survival pathways in in vitro studies. However, the role of neurotrophins in cell survival remains unclear in in vivo apoptotic neuronal cell death. We discuss the mechanism of neuroprotection by neurotrophins and also discuss cell survival effect of nerve growth factor on apoptotic neuronal cell death after in vivo cerebral ischemia.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalCurrent Atherosclerosis Reports
Volume7
Issue number4
DOIs
Publication statusPublished - 2005 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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