Neuroprotective kaurane diterpenes from Fritillaria ebeiensis

Jing Xu; Ping Guo; Cuizhou Liu; Zhanping Sun; Liping Gui; Yuanqiang Guo; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1271/bbb.110146

Neuroprotective kaurane diterpenes from Fritillaria ebeiensis

Jing Xu, Ping Guo, Cuizhou Liu, Zhanping Sun, Liping Gui, Yuanqiang Guo, Tohru Yamakuni, Yasushi Ohizumi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The new kaurane diterpene, ent-3β-butanoyloxykaur- 15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP ⁺-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

Original language	English
Pages (from-to)	1386-1388
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	75
Issue number	7
DOIs	https://doi.org/10.1271/bbb.110146
Publication status	Published - 2011

Keywords

Dietrpenoids
Fritillaria ebeiensis
Kaurane
Neuroprotective e.ffect.

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.110146

Cite this

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title = "Neuroprotective kaurane diterpenes from Fritillaria ebeiensis",

abstract = "The new kaurane diterpene, ent-3β-butanoyloxykaur- 15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP +-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.",

keywords = "Dietrpenoids, Fritillaria ebeiensis, Kaurane, Neuroprotective e.ffect.",

author = "Jing Xu and Ping Guo and Cuizhou Liu and Zhanping Sun and Liping Gui and Yuanqiang Guo and Tohru Yamakuni and Yasushi Ohizumi",

note = "Funding Information: This project was supported by the Fundamental Research Fund for Central Universities of China.",

year = "2011",

doi = "10.1271/bbb.110146",

language = "English",

volume = "75",

pages = "1386--1388",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "7",

}

TY - JOUR

T1 - Neuroprotective kaurane diterpenes from Fritillaria ebeiensis

AU - Xu, Jing

AU - Guo, Ping

AU - Liu, Cuizhou

AU - Sun, Zhanping

AU - Gui, Liping

AU - Guo, Yuanqiang

AU - Yamakuni, Tohru

AU - Ohizumi, Yasushi

N1 - Funding Information: This project was supported by the Fundamental Research Fund for Central Universities of China.

PY - 2011

Y1 - 2011

N2 - The new kaurane diterpene, ent-3β-butanoyloxykaur- 15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP +-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

AB - The new kaurane diterpene, ent-3β-butanoyloxykaur- 15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP +-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

KW - Dietrpenoids

KW - Fritillaria ebeiensis

KW - Kaurane

KW - Neuroprotective e.ffect.

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DO - 10.1271/bbb.110146

M3 - Article

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AN - SCOPUS:79960771803

VL - 75

SP - 1386

EP - 1388

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 7

ER -

Neuroprotective kaurane diterpenes from Fritillaria ebeiensis

Abstract

Keywords

ASJC Scopus subject areas

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