Neuroprotective kaurane diterpenes from Fritillaria ebeiensis

Jing Xu, Ping Guo, Cuizhou Liu, Zhanping Sun, Liping Gui, Yuanqiang Guo, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The new kaurane diterpene, ent-3β-butanoyloxykaur- 15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP +-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

Original languageEnglish
Pages (from-to)1386-1388
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number7
DOIs
Publication statusPublished - 2011

Keywords

  • Dietrpenoids
  • Fritillaria ebeiensis
  • Kaurane
  • Neuroprotective e.ffect.

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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