Neuroprotective effects of an antioxidant in cortical cerebral ischemia: Prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme

Yung Yee Chang, Miki Fujimura, Yuiko Morita-Fujimura, Gyung Whan Kim, Chiung Ying Huang, Hsiu Shan Wu, Makoto Kawase, Jean Christophe Copin, Pak H. Chan

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We examined the effects of the free radical scavenger, 21-aminosteroid, on apurinic/apyrimidinic endonuclease (APE/Ref-1) protein expression and subsequent infarction volume after photothrombotic cortical cerebral ischemia in mice. Immunohistochemistry and Western blot analysis showed a significant reduction in APE/Ref-1 expression 6 and 24 h after ischemia in untreated animals, whereas in drug-treated animals the reduction was much less at the same time points. The administration of 21-aminosteroid significantly decreased subsequent infarction volume 3 days after ischemia. These data suggest that 21-aminosteroid prevents the early decrease of APE/Ref-1 expression, thereby reducing cortical infarction after photothrombotic cerebral ischemia. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalNeuroscience Letters
Volume277
Issue number1
DOIs
Publication statusPublished - 1999 Dec 17

Keywords

  • Apurinic/apyrimidinic endonuclease
  • DNA base excision repair
  • Free radical scavenger
  • Photothiombotic cortical cerebral ischemia
  • Reactive oxygen species

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Chang, Y. Y., Fujimura, M., Morita-Fujimura, Y., Kim, G. W., Huang, C. Y., Wu, H. S., Kawase, M., Copin, J. C., & Chan, P. H. (1999). Neuroprotective effects of an antioxidant in cortical cerebral ischemia: Prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme. Neuroscience Letters, 277(1), 61-64. https://doi.org/10.1016/S0304-3940(99)00799-5