Neuroprotective effect of latanoprost on rat retinal ganglion cells

Hideyo Kudo, Toru Nakazawa, Masahiko Shimura, Hidetoshi Takahashi, Nobuo Fuse, Kenji Kashiwagi, Makoto Tamai

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Background: To investigate the neuroprotective effect of intravitreal administration of latanoprost on retinal ganglion cell (RGC) damage induced by N-methyl-D-aspartic acid (NMDA) or optic nerve axotomy. Methods: Using Sprague-Dawley rats, retinal ganglion cell damage was induced by either intravitreal administration of NMDA or optic nerve axotomy. Latanoprost at doses of 0.03, 0.3, 3, 30 and 300 pmol was administered intravitreally before NMDA injection or optic nerve axotomy. Retinal damage was evaluated by counting the number of surviving RGCs retrogradely labeled with fluorogold under the microscope. Results: Seven days after the NMDA injury, the number of su rviving RGCs was significantly increased at doses of more than 30 pmol atanoprost (846±178 cells/mm2 P=0.0166) compared with vehicle control (556±122 cells/mm2). Ten days after the optic nerve axotomy, the number of surviving RGC was significantly increased even at a dose of 0.3 pmol (815±239 cells/mm2, P=0.0359) compared with control (462±75 cells/mm2). Co nclusions: Intravitreal administration of latanoprost has a neuroprotective effect on rat RGC damage induced by either NMDA or optic nerve axotomy, while its pharmacological features are different.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume244
Issue number8
DOIs
Publication statusPublished - 2006 Aug

Keywords

  • Axotomy
  • Glaucoma
  • Latanoprost
  • N-Methyl-D-aspartic acid
  • Neuroprotection
  • Retinal ganglion ganglion cell

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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