TY - JOUR
T1 - Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner
AU - Hiraki-Kajiyama, Towako
AU - Yamashita, Junpei
AU - Yokoyama, Keiko
AU - Kikuchi, Yukiko
AU - Nakajo, Mikoto
AU - Miyazoe, Daichi
AU - Nishiike, Yuji
AU - Ishikawa, Kaito
AU - Hosono, Kohei
AU - Kawabata-Sakata, Yukika
AU - Ansai, Satoshi
AU - Kinoshita, Masato
AU - Nagahama, Yoshitaka
AU - Okubo, Kataaki
N1 - Funding Information:
Ministry of Education, Culture, Sports, Science, and Technology 25132705, Ministry of Education, Culture, Sports, Science and Technology 17H06429, Japan Society for the Promotion of Science 16H04979, Japan Society for the Promotion of Science 19H03044, Japan Society for the Promotion of Science 12J07446.
Publisher Copyright:
© Hiraki-Kajiyama et al.
PY - 2019/8
Y1 - 2019/8
N2 - Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.
AB - Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.
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U2 - 10.7554/eLife.39495
DO - 10.7554/eLife.39495
M3 - Article
C2 - 31383257
AN - SCOPUS:85071163994
VL - 8
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e39495
ER -