Neuronal apolipoprotein e receptor 2 immunoreactivity in Alzheimer's disease

Yumiko Motoi; Tadao Iwasaki; Hiroaki Hattori; Takako Aizawa; Seichi Haga; Satoshi Nakamura; Koichi Wakabayashi; Hitoshi Takahashi; Tokuo Yamamoto; Kazuhiko Ikeda

Neuronal apolipoprotein e receptor 2 immunoreactivity in Alzheimer's disease

Yumiko Motoi, Tadao Iwasaki, Hiroaki Hattori, Takako Aizawa, Seichi Haga, Satoshi Nakamura, Koichi Wakabayashi, Hitoshi Takahashi, Tokuo Yamamoto, Kazuhiko Ikeda

Division of Aging Science

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Apolipoprotein E receptor 2 (apoER2) is a new member of the LDL-receptor family, predominantly expressed in the brain. We raised a monoclonal antibody to apoER2 and examined immunohistochemically hippocampal tissue from the brains of patients with Alzheimer's disease (AD) and controls. ApoER2 immunoreactivity was present exclusively in neurons. The staining intensity of neurons measured by an image analyzer, was significantly stronger in AD, but this was not correlated with allele dosage of apoE ε4. These results suggest that apoER2 is upregulated in hippocampal neurons within AD.

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	Alzheimer's Reports
Volume	2
Issue number	2
Publication status	Published - 1999

ASJC Scopus subject areas

Neurology
Clinical Neurology

Cite this

Neuronal apolipoprotein e receptor 2 immunoreactivity in Alzheimer's disease. / Motoi, Yumiko; Iwasaki, Tadao; Hattori, Hiroaki; Aizawa, Takako; Haga, Seichi; Nakamura, Satoshi; Wakabayashi, Koichi; Takahashi, Hitoshi; Yamamoto, Tokuo; Ikeda, Kazuhiko.

In: Alzheimer's Reports, Vol. 2, No. 2, 1999, p. 87-91.

Research output: Contribution to journal › Article › peer-review

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AU - Motoi, Yumiko

AU - Iwasaki, Tadao

AU - Hattori, Hiroaki

AU - Aizawa, Takako

AU - Haga, Seichi

AU - Nakamura, Satoshi

AU - Wakabayashi, Koichi

AU - Takahashi, Hitoshi

AU - Yamamoto, Tokuo

AU - Ikeda, Kazuhiko

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AB - Apolipoprotein E receptor 2 (apoER2) is a new member of the LDL-receptor family, predominantly expressed in the brain. We raised a monoclonal antibody to apoER2 and examined immunohistochemically hippocampal tissue from the brains of patients with Alzheimer's disease (AD) and controls. ApoER2 immunoreactivity was present exclusively in neurons. The staining intensity of neurons measured by an image analyzer, was significantly stronger in AD, but this was not correlated with allele dosage of apoE ε4. These results suggest that apoER2 is upregulated in hippocampal neurons within AD.

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Neuronal apolipoprotein e receptor 2 immunoreactivity in Alzheimer's disease

Abstract

ASJC Scopus subject areas

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