Neuronal apolipoprotein e receptor 2 immunoreactivity in Alzheimer's disease

Yumiko Motoi, Tadao Iwasaki, Hiroaki Hattori, Takako Aizawa, Seichi Haga, Satoshi Nakamura, Koichi Wakabayashi, Hitoshi Takahashi, Tokuo Yamamoto, Kazuhiko Ikeda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Apolipoprotein E receptor 2 (apoER2) is a new member of the LDL-receptor family, predominantly expressed in the brain. We raised a monoclonal antibody to apoER2 and examined immunohistochemically hippocampal tissue from the brains of patients with Alzheimer's disease (AD) and controls. ApoER2 immunoreactivity was present exclusively in neurons. The staining intensity of neurons measured by an image analyzer, was significantly stronger in AD, but this was not correlated with allele dosage of apoE ε4. These results suggest that apoER2 is upregulated in hippocampal neurons within AD.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalAlzheimer's Reports
Issue number2
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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