Neuromodulator octopamine attenuates extrajunctional glutamate sensitivity in insect muscle

Daisuke Yamamoto, Sachiyo Ishikawa

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Octopamine was found to decrease extrajunctional, but not junctional glutamate responses, in mealworm neuromuscular preparations. This action of octopamine was mimicked by forskolin, 8‐(4‐chlorophenylthio)‐adenosine 3′:5′‐cyclic monophosphate (CPT‐cyclic AMP), and 8‐bromoguanosine 3′:5′‐cyclic monophosphate (8‐bromo‐cyclic GMP), but not by 1,2‐oleoylacetylglycerol (OAG), a protein kinase C activator. We suggest that the octopamine‐induced reduction in the glutamate sensitivity of extrajunctional membranes may enable the muscle to more closely follow its neuronal input by preventing a depolarization (and hence a conductance increase) due to the discharge of unsequestered transmitter molecules at nonsynaptic sites.

    Original languageEnglish
    Pages (from-to)265-272
    Number of pages8
    JournalArchives of Insect Biochemistry and Physiology
    Volume18
    Issue number4
    DOIs
    Publication statusPublished - 1991

    Keywords

    • amino acid receptor
    • biogenic amine
    • cyclic nucleotides
    • mealworm

    ASJC Scopus subject areas

    • Physiology
    • Biochemistry
    • Insect Science

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