Neuromagnetic evidence of abnormal automatic inhibitory function in subjective memory complaint

Hua Hsuan Sun, Mei Yin Lin, Rui Nouchi, Pei Ning Wang, Chia Hsiung Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

Subjective memory complaint (SMC), a self-perceived worsening in memory capacity concurrent with normal performance on standardized cognitive assessments, is considered a risk factor for the development of Alzheimer's disease (AD). Deficient sensory gating (SG), referring to the lack of automatic inhibition of neural responses to the second identical stimulus, has been documented in prodromal and incident AD patients. However, it remains unknown whether the cognitively normal elderly with SMC demonstrate alterations of SG function compared with those without SMC. A total of 19 healthy controls (HC) and 16 SMC subjects were included in the present study. Neural responses to the auditory paired-stimulus paradigm were recorded by the magnetoencephalography and analyzed by the distributed source imaging method of minimum norm estimate. The SG of M50 and M100 components were measured using the amplitude ratio of the second response over the first response at the cortical level. Compared to HC, subjects with SMC showed significantly increased M50 SG ratios in the inferior parietal lobule (IPL). Furthermore, M50 SG ratios in the right IPL yielded an acceptable discriminative ability to distinguish SMC from HC. However, we did not find a significant association between SG ratios and cognitive function requiring inhibitory control either in the HC or SMC group. In conclusion, although SMC subjects have intact cognitive functioning revealed by objective neuropsychological tests, their deficits in automatic inhibitory function could be detected through neurophysiological recordings. Our results suggest that altered brain function occurs in SMC prior to the obvious decline of cognitive performance.

Original languageEnglish
JournalEuropean Journal of Neuroscience
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Alzheimer's disease
  • inferior parietal lobule
  • magnetoencephalography
  • sensory gating
  • subjective cognitive decline
  • subjective memory complaint

ASJC Scopus subject areas

  • Neuroscience(all)

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