Neurologic Abnormalities in Two Dogs Suspected Lyme Disease

Yuzo Azuma, Katsuzi Kawamura, Hiroshi Lsogai, Emiko Isogai

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    A 2-year-old mongrel dog developed neurological signs following tick bite. These included astasia, persistent tonic convulsions and hyper-reflexia. Both serum IgG and IgM antibody titers against Borrelia burgdorferi were positive in enzyme-linked immunosorbent assay (ELISA). The neurological signs subsided after high-dose penicillin and streptomycin treatment. A strain of spirochetes (P427a) was isolated from the midgut of Ixodes persulcatus feeding on the dog. Morphological characteristic, immunological property and protein profile revealed that the isolate was B. burgdorferi. Similarly, a 2-year-old Labrador retriever dog developed neurological signs after tick bite and showed a positive IgG antibody titer against B. burgdorferi. Antibiotic treatment was effective also in this case. These findings suggest that neurological symptoms shown in both dogs were caused by infection with B. burgdorferi.

    Original languageEnglish
    Pages (from-to)325-329
    Number of pages5
    Issue number4
    Publication statusPublished - 1993


    • Dog
    • Neuro-Lyme disease

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology


    Dive into the research topics of 'Neurologic Abnormalities in Two Dogs Suspected Lyme Disease'. Together they form a unique fingerprint.

    Cite this