Neurologic Abnormalities in Two Dogs Suspected Lyme Disease

Yuzo Azuma, Katsuzi Kawamura, Hiroshi Lsogai, Emiko Isogai

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A 2-year-old mongrel dog developed neurological signs following tick bite. These included astasia, persistent tonic convulsions and hyper-reflexia. Both serum IgG and IgM antibody titers against Borrelia burgdorferi were positive in enzyme-linked immunosorbent assay (ELISA). The neurological signs subsided after high-dose penicillin and streptomycin treatment. A strain of spirochetes (P427a) was isolated from the midgut of Ixodes persulcatus feeding on the dog. Morphological characteristic, immunological property and protein profile revealed that the isolate was B. burgdorferi. Similarly, a 2-year-old Labrador retriever dog developed neurological signs after tick bite and showed a positive IgG antibody titer against B. burgdorferi. Antibiotic treatment was effective also in this case. These findings suggest that neurological symptoms shown in both dogs were caused by infection with B. burgdorferi.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalMICROBIOLOGY and IMMUNOLOGY
Volume37
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • Dog
  • Neuro-Lyme disease

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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