Neurokinin A-like immunoreactivity in feline dental pulp: its distribution, origin and coexistence with substance P-like immunoreactivity

Satoshi Wakisaka, Hiroyuki Ichikawa, Shinji Nishikawa, Saburou Matsuo, Yoshiro Takano, Michio Akai

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The distribution and origin of neurokinin A (NKA)-like immunoreactivity were investigated in feline dental pulp by an indirect immunofluorescence method. NKA-containing nerve fibres with varicosities, which entered the dental pulp via apical foramen, were distributed throughout this tissue. Many NKA-containing nerve fibres were localized around blood vessels, but some were observed apart therefrom. At the odontoblastic layer, thin NKA-containing nerve fibres were observed running straight toward the pulp-predentinal border between odontoblasts. After inferior alveolar nerve section, all NKA-containing nerve fibres disappeared in the dental pulp, while the removal of the superior cervial ganglion resulted in no change in the distribution of these fibres. The correlation of NKA-like immunoreactivity and substance P (SP)-like immunoreactivity was also investigated by double-immunofluorescence technique. The distribution of NKA-containing nerve fibres was very similar to that of SP-containing nerve fibres; it appeared that all NKA-containing nerve fibres contained SP.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalCell and Tissue Research
Volume251
Issue number3
DOIs
Publication statusPublished - 1988 Mar

Keywords

  • Cat
  • Dental pulp
  • Immunohistochemistry
  • Neurokinin A
  • Substance P

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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