Neuroinflammation

Ocular inflammation is known to be accompanied by retinal cell impairment. In uveitis, there are numerous causes of the retinal cell damage. However, secondary intraocular hypertension and direct inflammation caused by the uveitis are major concerns, as both of these can affect retinal cell survival. This is especially the case in sarcoidosis and Vogt-Koyanagi-Harada disease, which are the most common types of uveitis seen clinically in Japan. In addition, Behçet's disease and acute retinal necrosis are also known to have a poor prognosis when patients are unable to receive precise treatments at specific time points during the clinical progress of the disease.