Neuroepidemiologic and Neurobehavioral Characteristics of Motoric Cognitive Risk Syndrome in an Old-Old Population: The Kurihara Project

Keiichi Kumai, Kenichi Meguro, Mari Kasai, Kei Nakamura, Masahiro Nakatsuka

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background: Recently, the concept of motoric cognitive risk (MCR) syndrome was proposed, where slow gait is considered a risk factor for conversion to dementia. Aim: To retrospectively investigate the characteristics of MCR among a population aged 75+ years, focusing on the aspects of epidemiology and neurobehavioral characteristics. Method: The participants were 590 residents aged 75+ years living in Kurihara who underwent MRI and neurobehavioral assessments including walking velocity. The prevalence of MCR and conversion to dementia (AD8 Dementia Screening Interview cutoff 2/8), together with the neurobehavioral characteristics of the MCR group, were analyzed. Results: The prevalence was 11.1%, and the conversion ratio in the MCR group was higher than that in the non-MCR group (OR = 1.38). The MCR group had lower scores on the executive function test as well as gait velocity. Conclusions: The MCR syndrome increases the rate of conversion to dementia, and both slow gait and lower scores in executive tests, which are 'frontal-based' functions, are predictive of higher rates of conversion to dementia.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalDementia and Geriatric Cognitive Disorders Extra
Volume6
Issue number2
DOIs
Publication statusPublished - 2016

Keywords

  • Executive function
  • Gait
  • Motoric cognitive risk syndrome

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health

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