TY - JOUR
T1 - Neuroepidemiologic and Neurobehavioral Characteristics of Motoric Cognitive Risk Syndrome in an Old-Old Population
T2 - The Kurihara Project
AU - Kumai, Keiichi
AU - Meguro, Kenichi
AU - Kasai, Mari
AU - Nakamura, Kei
AU - Nakatsuka, Masahiro
N1 - Publisher Copyright:
© 2016 The Author(s) Published by S. Karger AG, Basel.
PY - 2016
Y1 - 2016
N2 - Background: Recently, the concept of motoric cognitive risk (MCR) syndrome was proposed, where slow gait is considered a risk factor for conversion to dementia. Aim: To retrospectively investigate the characteristics of MCR among a population aged 75+ years, focusing on the aspects of epidemiology and neurobehavioral characteristics. Method: The participants were 590 residents aged 75+ years living in Kurihara who underwent MRI and neurobehavioral assessments including walking velocity. The prevalence of MCR and conversion to dementia (AD8 Dementia Screening Interview cutoff 2/8), together with the neurobehavioral characteristics of the MCR group, were analyzed. Results: The prevalence was 11.1%, and the conversion ratio in the MCR group was higher than that in the non-MCR group (OR = 1.38). The MCR group had lower scores on the executive function test as well as gait velocity. Conclusions: The MCR syndrome increases the rate of conversion to dementia, and both slow gait and lower scores in executive tests, which are 'frontal-based' functions, are predictive of higher rates of conversion to dementia.
AB - Background: Recently, the concept of motoric cognitive risk (MCR) syndrome was proposed, where slow gait is considered a risk factor for conversion to dementia. Aim: To retrospectively investigate the characteristics of MCR among a population aged 75+ years, focusing on the aspects of epidemiology and neurobehavioral characteristics. Method: The participants were 590 residents aged 75+ years living in Kurihara who underwent MRI and neurobehavioral assessments including walking velocity. The prevalence of MCR and conversion to dementia (AD8 Dementia Screening Interview cutoff 2/8), together with the neurobehavioral characteristics of the MCR group, were analyzed. Results: The prevalence was 11.1%, and the conversion ratio in the MCR group was higher than that in the non-MCR group (OR = 1.38). The MCR group had lower scores on the executive function test as well as gait velocity. Conclusions: The MCR syndrome increases the rate of conversion to dementia, and both slow gait and lower scores in executive tests, which are 'frontal-based' functions, are predictive of higher rates of conversion to dementia.
KW - Executive function
KW - Gait
KW - Motoric cognitive risk syndrome
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U2 - 10.1159/000445539
DO - 10.1159/000445539
M3 - Article
AN - SCOPUS:84966424771
VL - 6
SP - 176
EP - 182
JO - Dementia and Geriatric Cognitive Disorders Extra
JF - Dementia and Geriatric Cognitive Disorders Extra
SN - 1664-5464
IS - 2
ER -