Neural substrates of cognitive subtypes in Parkinson's disease: A 3-year longitudinal study

Yumiko Shoji, Yoshiyuki Nishio, Toru Baba, Makoto Uchiyama, Kayoko Yokoi, Toshiyuki Ishioka, Yoshiyuki Hosokai, Kazumi Hirayama, Hiroshi Fukuda, Masashi Aoki, Takafumi Hasegawa, Atsushi Takeda, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background: The neuropsychological features and neuropathological progression patterns associated with rapidly evolving cognitive decline or dementia in Parkinson's disease (PD) remain to be elucidated.

Methods: Fifty-three PD patients without dementia were recruited to participate in a 3-year longitudinal cohort study. The patients were grouped according to the Clinical Dementia Rating (CDR). Group-wise comparisons were made with regard to demographic characteristics, motor symptoms, neuropsychological performances and 18F-fluorodeoxyglucose positron emission tomography.

Results: Patients who had memory-plus cognitive impairment (patients whose CDR was 0 at baseline and 0.5 in memory and other domains at follow-up, and those whose baseline CDR was 0.5 in memory and other domains) exhibited higher age at onset, visuoperceptual impairment, non-tremor-dominant motor disturbance, rapid symptomatic progression and posterior neocortical hypometabolism. In patients who were cognitively unimpaired and those who had memory-dominant cognitive impairment (patients whose CDR was 0 at baseline and 0.5 only in memory domain at follow-up, and those whose baseline CDR was 0.5 only in memory domain), the posterior neocortex was relatively unaffected until a later stage of the disease.

Conclusions: These results suggest that visuoperceptual impairment and the early involvement of the posterior neocortex may be risk factors for rapid symptomatic progression and dementia in PD.

Original languageEnglish
Article numbere110547
JournalPloS one
Volume9
Issue number10
DOIs
Publication statusPublished - 2014 Oct 20

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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