Neural signal transmission measurements with a conductive polymer microelectrode array

Akiyoshi Shimada, Nahoko Kasai, Yuriko Furukawa, Tobias Nyberg, Keiichi Torimitsu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The neural activity of dissociated cultures of mouse cortical neurons was measured with a conductive polymer microelectrode array. Each electrode was electrochemically polymerized from (3,4-ethylenedioxythiophene)- poly(styrenesulfonate) and ethylenedioxythiophene on indium tin oxide electrodes. The spike activity of the cortical neurons was measured with the conducting polymer MEA and spike train cross-correlograms were calculated to predict the type of synaptic connection. Both excitatory and inhibitory synaptic connections were identified after 6 to 8 days in vitro. These results show that it is possible to determine the interaction between excitatory and inhibitory neurons in relation to information processing with this new polymer electrode.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalElectrical Engineering in Japan (English translation of Denki Gakkai Ronbunshi)
Volume177
Issue number1
DOIs
Publication statusPublished - 2011 Oct 1
Externally publishedYes

Keywords

  • conductive polymer
  • microelectrode array
  • neural network
  • spike
  • synaptic connection

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Energy Engineering and Power Technology

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