Neural signal transmission measurements with a conductive polymer microelectrode array

Akiyoshi Shimada, Nahoko Kasai, Yuriko Furukawa, Tobias Nyberg, Keiichi Torimitsu

Research output: Contribution to journalArticle

Abstract

The neural activity of dissociated cultures of mouse cerebral cortical neurons was measured with a conductive polymer microelectrode array. Each electrode was electrochemically polymerized from (3,4-ethylenedioxythiophene)- poly(styrenesulfonate) and ethylenedioxythiophene on indium tin oxide electrodes. The spike activity of the cortical neurons was measured with the conducting polymer MEA and spike train cross-correlograms were calculated to predict the type of synaptic connection. Both excitatory and inhibitory synaptic connections were identified after 6-8 days in vitro. These results show that it is possible to determine the interaction between excitatory and inhibitory neurons in relation to information processing with this new polymer electrode.

Original languageEnglish
JournalIEEJ Transactions on Electronics, Information and Systems
Volume129
Issue number2
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

Keywords

  • Conductive polymer
  • Microelectrode array
  • Neural network
  • Spike
  • Synaptic connection

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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