Abstract
Objectives: In our previous functional magnetic resonance imaging (fMRI) study, we determined that there was distinct left hemispheric dominance for lexical-semantic processing without the influence of human voice perception in right-handed healthy subjects. However, the degree of right-handedness in the right-handed subjects ranged from 52 to 100 according to the Edinburgh Handedness Inventory (EHI) score. In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing. Methods: Twenty-seven normal right-handed healthy subjects were scanned by fMRI while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND). Fronto-temporo- parietal activation was observed in the left hemisphere under the SEN - rSEN contrast, which included lexical-semantic processing without the influence of human voice perception. Laterality Index was calculated as LI = (L-R)/(L + R) x 100, L: left, R: right. Results: Laterality Index in the fronto-temporo-parietal cortices did not correlate with the degree of right-handedness in EHI score. Conclusions: The present study indicated that the degree of right-handedness from 52 to 100 in EHI score had no effect on the degree of left hemispheric dominance for lexical-semantic processing in right-handed healthy subjects.
Original language | English |
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Pages (from-to) | 247-250 |
Number of pages | 4 |
Journal | Methods of Information in Medicine |
Volume | 46 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2007 Jan 1 |
Keywords
- Cerebral laterality
- Handedness
- Laterality index
- Lexical-semantic processing
- fMRI
ASJC Scopus subject areas
- Health Informatics
- Advanced and Specialised Nursing
- Health Information Management