Neural interfacing non-invasive brain stimulation with NIRS-EEG joint imaging for closed-loop control of neuroenergetics in ischemic stroke

Alexander Von Luhmann, Jessica Addesa, Sourav Chandra, Abhijit Das, Mitsuhiro Hayashibe, Anirban Dutta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Stroke can be defined as a sudden onset of neurological deficits caused by a focal injury to the central nervous system from a vascular cause. In ischemic stroke (∼87% of all strokes) and transient ischemic attack (TIA), the blood vessel carrying blood to the brain is blocked causing deficit in the glucose supply - the main energy source. Here, neurovascular coupling (NVC) mechanism links neural activity with the corresponding blood flow that supplies glucose and oxygen for neuronal energy. Brain accounts for about 25% of total glucose consumption while being 2% of the total body weight. Therefore, a deficit in glucose supply can quickly change brain's energy supply chain that can be transient (in TIA) or longer lasting (in stroke, vascular dementia). Here, implications of the failure of brain's energy supply chain can be dysfunctional brain networks in cerebrovascular diseases. Using near-infrared spectroscopy (NIRS) in conjunction with electroencephalography (EEG), a non-invasive, real-time and point of care method to monitor the neuroenergetic status of the cortical gray matter is proposed. Furthermore, we propose that NIRS-EEG joint-imaging can be used to dose non-invasive brain stimulation (NIBS) - transcranial direct current stimulation (tDCS) and photobiomodulation - which may be able to provide therapeutic options for patients with energetic insufficiency by modulating the cortical neural activity and hemodynamics.

Original languageEnglish
Title of host publication8th International IEEE EMBS Conference on Neural Engineering, NER 2017
PublisherIEEE Computer Society
Pages349-353
Number of pages5
ISBN (Electronic)9781538619162
DOIs
Publication statusPublished - 2017 Aug 10
Externally publishedYes
Event8th International IEEE EMBS Conference on Neural Engineering, NER 2017 - Shanghai, China
Duration: 2017 May 252017 May 28

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other8th International IEEE EMBS Conference on Neural Engineering, NER 2017
CountryChina
CityShanghai
Period17/5/2517/5/28

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

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