Neural crest and placode contributions to olfactory development

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

Olfaction is the sense of smell that influences many primitive behaviors for survival, e.g., feeding, reproduction, social interaction, and fear response. The olfactory system is an evolutionarily ancient sensory system and composed of the olfactory epithelium (OE), the olfactory bulb (OB), and the olfactory cortex. The OE gives rise to olfactory receptor neurons (ORNs), i.e., primary sensory receptor cells whose axons project directly to the OB. The ORNs are unique in the way that they are continuously replaced during physiological turnover or following injury throughout life. In the OE, horizontal basal cells, i.e., flat and quiescent cells attached to the basal lamina, are now thought to be tissue stem cells. Although OE cells, especially ORNs, were hypothesized to be derived from the olfactory placode (OP), recent genetic fate-mapping studies using Cre reporter mice indicate a dual origin, i.e., the OP and neural crest (NC), of the olfactory system. The NC is a transient embryonic tissue that is formed between the dorsal neuroepithelium and epidermis. Neural crest cells (NCCs) are multipotent cells that migrate into various target tissues and differentiate into various cell types, including neurons and glia of the peripheral nervous system, cranial cartilage and bone, and melanocytes. Recent studies have revealed that neural crest-derived cells (NCDCs) are widely distributed in adult tissues, and that a subset of NCDCs still possesses NCC-like multipotency. Here, we review classical and recent studies of the olfactory system, especially focusing on the contribution of the NC and OP to the OE development.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages351-374
Number of pages24
DOIs
Publication statusPublished - 2015

Publication series

NameCurrent Topics in Developmental Biology
Volume111
ISSN (Print)0070-2153

Keywords

  • Horizontal basal cell
  • Neural crest
  • Olfactory ensheathing cell
  • Olfactory epithelium
  • Olfactory placode
  • Olfactory system

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Neural crest and placode contributions to olfactory development'. Together they form a unique fingerprint.

Cite this