Neostriatal mosaic and type II Ca2+/calmodulin-dependent protein kinase: An immunohistochemical study on the adult rat striatum

Satoshi Goto, Kazumichi Yamada, Yukitaka Ushio, Kohji Fukunaga, Eishichi Miyamoto

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8 Citations (Scopus)

Abstract

The present immunohistochemical study is concerned with the expression of type II Ca2+/calmodulin-dependent protein kinase (CaM-kinase II), which is supposed to play an essential role in the intracellular Ca2+ signal transduction, in the striatum of adult rats. CaM-kinase II immunoreactivity was differentially concentrated in irregularly shaped compartments within the nucleus in a mosaic-like fashion. The compartment of heightened CaM-kinase II-immunolabeling corresponded to the extrastriosomal matrix visualized by calbindin-D28k-immunostaining. Light microscopic observation showed neurons immunoreactive for CaM-kinase II to be less densely distributed in the striosomes than in the matrix compartment. The present data suggest that these two striatal compartments may differ in an intracellular Ca2+-signaling process associated with protein phosphorylation.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume173
Issue number1-2
DOIs
Publication statusPublished - 1994 May 23
Externally publishedYes

Keywords

  • Calbindin-D
  • Immunohistochemistry
  • Neurochemical compartmentalization
  • Rat
  • Striatum
  • Type II Ca/calmodulin-dependent protein kinase

ASJC Scopus subject areas

  • Neuroscience(all)

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