Neonatal testosterone imprinting of hepatic microsomal drug metabolism and a male-specific form of cytochrome P-450 in the rat

Tetsuya Kamataki, Kaori Maeda, Miki Shimada, Tsuneji Nagai, Ryuichi Kato

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    The effects of neonatal castration and treatment with testosterone on sex-specific forms of cytochrome P-450, namely P-450-male and P-450-female, were studied. Neonatal castration of male rats resulted in a change in the population of forms of cytochrome P-450. Castration 1 day after birth abolished the synthesis of P-450-male and stimulated the synthesis of P-450-female. The decrease in the amount of P-450-male as well as the activities of drug metabolizing enzymes was partially reversed by administration of testosterone after castration.

    Original languageEnglish
    Pages (from-to)1939-1942
    Number of pages4
    JournalJournal of biochemistry
    Volume96
    Issue number6
    DOIs
    Publication statusPublished - 1984 Oct

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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