Neoechinulin a protects PC12 cells against MPP+-induced cytotoxicity

Yoshihito Kajimura, Toshiaki Aoki, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Nobuo Watanabe, Takao Arai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Neoechinulin A, an alkaloid from Eurotium rubrum, can protect neuronal PC12 cells against cytotoxicity of a potent oxidant, peroxynitrite. Because involvement of peroxynitrite has been suggested in the pathogenesis of Parkinson's disease, we assessed whether this alkaloid could also protect PC12 cells from the cytocidal action of 1-methyl-4-phenylpyridine (MPP+), a neurotoxin capable of provoking acute Parkinson's-like neurodegeneration in humans. Neoechinulin A could protect PC12 cells from MPP+ cytotoxicity without protecting against mitochondrial complex I dysfunction, suggesting the alkaloid can ameliorate downstream events of mitochondrial failure. Thus, neoechinulin A has the potential to intervene in this progressive neurodegeneration.

Original languageEnglish
Pages (from-to)330-333
Number of pages4
JournalJournal of Antibiotics
Volume61
Issue number5
DOIs
Publication statusPublished - 2008 May

Keywords

  • Alkaloid
  • Neurodegeneration
  • Parkinson's disease
  • Reactive oxygen/nitrogen species

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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