Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract

Naomi Tomioka, Noriko Osumi, Yasufumi Sato, Takayoshi Inoue, Shun Nakamura, Hajime Fujisawa, Tatsumi Hirata

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

The early-generated neurons designated as lot cells specifically mark the future site of the lateral olfactory tract (LOT) and guide LOT axons. We investigated the mechanism of how lot cells develop and get localized in the LOT position. Lot cells differentiated from neuroepithelial cells in all regions of the neocortex but not from those in the ganglionic eminence in culture. Cell tracing analyses demonstrated that lot cells generated from the neocortex subsequently followed a tangential migration stream ventrally toward the LOT position. Mutant mouse embryos lacking the function of transcription factor Gli3 showed disturbances of the migration stream and translocation of lot cells in the dorsal telencephalon. These results reveal a new type of neuronal migration in the telencephalon and introduce an unexpected dramatic feature of the earliest regionalization of the telencephalon.

Original languageEnglish
Pages (from-to)5802-5812
Number of pages11
JournalJournal of Neuroscience
Volume20
Issue number15
DOIs
Publication statusPublished - 2000 Aug 1

Keywords

  • Gli3
  • Guidepost
  • Lot cell
  • Migration
  • Neurogenesis
  • Xt

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract'. Together they form a unique fingerprint.

Cite this