Neither MafA/L-Maf nor MafB is essential for lens development in mice

Takashi Takeuchi, Takashi Kudo, Kiyohito Ogata, Michito Hamada, Megumi Nakamura, Katsumi Kito, Yasuhito Abe, Norifumi Ueda, Masayuki Yamamoto, James Douglas Engel, Satoru Takahashi

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21 Citations (Scopus)

Abstract

The importance of the large Maf transcription factor family has been investigated in lens development in the chick, Xenopus and mammals. Previously we reported that c-maf -deficient mice exhibit severe defects in lens fibre cells. Here, we report the roles of other large Mafs, MafA/ L-Maf and MafB, during mouse lens development. MafA/L-Maf and MafB were expressed in lens epithelial cells and fibre cells at E12.5 but had largely disappeared from the lens at E18.5. The lens of mafA-, mafB-deficient and mafA::mafB double-deficient mice developed normally. In c-maf-deficient mice, the pattern of expression of MafA and MafB differed from their expression in wild-type mice. Moreover, the expression of crystallin genes was unchanged in mafA-, mafB- and mafA::mafB double-deficient lens. These results indicate that c-Maf alone is essential for lens development, and that MafA/L-Maf and MafB are dispensable in mice.

Original languageEnglish
Pages (from-to)941-947
Number of pages7
JournalGenes to Cells
Volume14
Issue number8
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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    Takeuchi, T., Kudo, T., Ogata, K., Hamada, M., Nakamura, M., Kito, K., Abe, Y., Ueda, N., Yamamoto, M., Engel, J. D., & Takahashi, S. (2009). Neither MafA/L-Maf nor MafB is essential for lens development in mice. Genes to Cells, 14(8), 941-947. https://doi.org/10.1111/j.1365-2443.2009.01321.x