Nectrianolins A, B, and C, new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP

Nanang Rudianto Ariefta, Priska Kristiana, Handojo Hadi Nurjanto, Hiroyuki Momma, Eunsang Kwon, Tatsuya Ashitani, Keitaro Tawaraya, Tetsuya Murayama, Takuya Koseki, Hiroshi Furuno, Narandulam Usukhbayar, Ken ichi Kimura, Yoshihito Shiono

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Two sesquiterpene-epoxycyclohexenone conjugates, nectrianolins A (1) and B (2), together with a sesquiterpene, nectrianolin C (3), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP, an endophytic fungus isolated from Gliricidia sepium. Their structures were determined on the basis of 1D-/2D-NMR spectroscopy and HRESIMS data analyses in combination with chemical means. Nectrianolins A–C (1–3) exhibited cytotoxic activity against both HL60 and HeLa cells.

Original languageEnglish
Pages (from-to)4082-4086
Number of pages5
JournalTetrahedron Letters
Volume58
Issue number43
DOIs
Publication statusPublished - 2017

Keywords

  • Cytotoxicity
  • Endophyte
  • Nectria pseudotrichia
  • Nectrianolins

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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