Ncx, a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells

Masahiko Hatano, Yoshinori Iitsuka, Hiroyuki Yamamoto, Mari Dezawa, Seiichi Yusa, Yoichi Kohno, Takeshi Tokuhisa

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

We have isolated the murine homeobox gene (Ncx) that belong to a Hox11 gene family. Expression of the Ncx gene was analyzed in total RNAs from embryos by reverse transcribed polymerase chain reaction (RT-PCR). The mRNA was detected in embryos after 9.5 days of embryogenesis (E9.5) and was maximal at E12.5. The RT-PCR also detected the message in total RNAs from adrenal glands and intestine in adult mice. The expression was further examined in various tissues from embryos by in situ hybridization. It was detected in dorsal root ganglia, cranial nerve ganglia (V, IX, X), enteric nerve ganglia and adrenal glands from embryos between E9.5 and E13.5. Since its expression is restricted to tissues derived from neural crest cells, Ncx may play a role in differentiation and proliferation of neural crest lineage cells.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalAnatomy and Embryology
Volume195
Issue number5
DOIs
Publication statusPublished - 1997 Jun 6
Externally publishedYes

Keywords

  • Adrenal glands
  • Dorsal root ganglia
  • Enteric ganglia
  • Homeobox
  • Sympathetic nerve

ASJC Scopus subject areas

  • Anatomy
  • Embryology
  • Developmental Biology
  • Cell Biology

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