Naturally Occurring Hemolysin in the Marine Snail Tugali gigas

Hisao Kamiya; Koji Muramoto; Rina Goto

doi:10.2331/suisan.57.2109

Naturally Occurring Hemolysin in the Marine Snail Tugali gigas

Hisao Kamiya, Koji Muramoto, Rina Goto

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The hemolymph of the marine snail Tugali gigas contains a potent hemolysin. Hemolysin was a protein in nature, and was heat-labile. Hemolytic activity was dependent on the presence of calcium ions. It was sensitive to the treatment with 2-mercaptoethanoI or trypsin. Freezing the hemolymph also destroyed the hemolytic activity. The sugars such as D-mannosamine, AT-acetyl-D-mannosamine, and also mucin Type II depressed the hemolytic activity of the hemolymph. Zymosan or sphingomyelin did not absorb the hemolysin in the T. gigas hemolymph. No cyto-toxicity against murine tumor cells nor the growth inhibition against a marine bacterium were observed.

Original language	English
Pages (from-to)	2109-2113
Number of pages	5
Journal	Nippon Suisan Gakkaishi (Japanese Edition)
Volume	57
Issue number	11
DOIs	https://doi.org/10.2331/suisan.57.2109
Publication status	Published - 1991 Jan 1

ASJC Scopus subject areas

Aquatic Science

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title = "Naturally Occurring Hemolysin in the Marine Snail Tugali gigas",

abstract = "The hemolymph of the marine snail Tugali gigas contains a potent hemolysin. Hemolysin was a protein in nature, and was heat-labile. Hemolytic activity was dependent on the presence of calcium ions. It was sensitive to the treatment with 2-mercaptoethanoI or trypsin. Freezing the hemolymph also destroyed the hemolytic activity. The sugars such as D-mannosamine, AT-acetyl-D-mannosamine, and also mucin Type II depressed the hemolytic activity of the hemolymph. Zymosan or sphingomyelin did not absorb the hemolysin in the T. gigas hemolymph. No cyto-toxicity against murine tumor cells nor the growth inhibition against a marine bacterium were observed.",

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AU - Kamiya, Hisao

AU - Muramoto, Koji

AU - Goto, Rina

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N2 - The hemolymph of the marine snail Tugali gigas contains a potent hemolysin. Hemolysin was a protein in nature, and was heat-labile. Hemolytic activity was dependent on the presence of calcium ions. It was sensitive to the treatment with 2-mercaptoethanoI or trypsin. Freezing the hemolymph also destroyed the hemolytic activity. The sugars such as D-mannosamine, AT-acetyl-D-mannosamine, and also mucin Type II depressed the hemolytic activity of the hemolymph. Zymosan or sphingomyelin did not absorb the hemolysin in the T. gigas hemolymph. No cyto-toxicity against murine tumor cells nor the growth inhibition against a marine bacterium were observed.

AB - The hemolymph of the marine snail Tugali gigas contains a potent hemolysin. Hemolysin was a protein in nature, and was heat-labile. Hemolytic activity was dependent on the presence of calcium ions. It was sensitive to the treatment with 2-mercaptoethanoI or trypsin. Freezing the hemolymph also destroyed the hemolytic activity. The sugars such as D-mannosamine, AT-acetyl-D-mannosamine, and also mucin Type II depressed the hemolytic activity of the hemolymph. Zymosan or sphingomyelin did not absorb the hemolysin in the T. gigas hemolymph. No cyto-toxicity against murine tumor cells nor the growth inhibition against a marine bacterium were observed.

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