TY - JOUR
T1 - Natural killer (NK) cells in HTLV-I-associated myelopathy/tropical spastic paraparesis - decrease in NK cell subset populations and activity in HTLV-I seropositive individuals
AU - Yu, Feng
AU - Itoyama, Yasuto
AU - Fujihara, Kazuo
AU - Goto, Ikuo
N1 - Funding Information:
We thank Dr. Josephine S. Casanova and Dr. Brian T. Quinn for comments on the manuscript. This work was supported by a Grant-in-Aid for General Scientific Research (No. 63480217), from the Ministry of Education, Science and Culture, and by grants from the Neuroimmunological Disease Research Committee and from the Slow Virus Infection Research Committee, the Min-islry of Health and Welfare of Japan.
PY - 1991/8
Y1 - 1991/8
N2 - We examined natural killer (NK) cell activity and NK cell subset populations in 18 patients with HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP), ten HTLV-I seropositive asymptomatic carriers and 20 seronegative healthy controls. The NK cell activity was significantly decreased in HAM/TSP, compared with that in controls. The percentages of NK cell subsets, such as CD16+, CD11b+, CD56+, CD16+CD56-, CD16-CD56+, CD16+CD8-, or CD16+CD3+ cells were significantly decreased in HAM/TSP patients. Of particular interest is that the percentage of CD16+CD3+ cells, which have a wide spectrum of cytotoxic properties commonly seen in NK, lymphokine activated killer (LAK) and antibody-dependent cellular-cytotoxic (ADCC) effector cells, was significantly decreased in HAM/TSP as compared to asymptomatic carriers as well as controls. The percentage of CD16+CD3+ cells correlated inversely with the value of spontaneous proliferation of peripheral blood lymphocytes (SPP), which is a characteristic change observed in HAM/TSP.
AB - We examined natural killer (NK) cell activity and NK cell subset populations in 18 patients with HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP), ten HTLV-I seropositive asymptomatic carriers and 20 seronegative healthy controls. The NK cell activity was significantly decreased in HAM/TSP, compared with that in controls. The percentages of NK cell subsets, such as CD16+, CD11b+, CD56+, CD16+CD56-, CD16-CD56+, CD16+CD8-, or CD16+CD3+ cells were significantly decreased in HAM/TSP patients. Of particular interest is that the percentage of CD16+CD3+ cells, which have a wide spectrum of cytotoxic properties commonly seen in NK, lymphokine activated killer (LAK) and antibody-dependent cellular-cytotoxic (ADCC) effector cells, was significantly decreased in HAM/TSP as compared to asymptomatic carriers as well as controls. The percentage of CD16+CD3+ cells correlated inversely with the value of spontaneous proliferation of peripheral blood lymphocytes (SPP), which is a characteristic change observed in HAM/TSP.
KW - Human T lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
KW - Lymphocyte subset
KW - Monoclonal antibody
KW - Natural killer cell
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U2 - 10.1016/0165-5728(91)90056-D
DO - 10.1016/0165-5728(91)90056-D
M3 - Article
C2 - 2066395
AN - SCOPUS:0025800102
VL - 33
SP - 121
EP - 128
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
SN - 0165-5728
IS - 2
ER -