Natural killer (NK) cells in HTLV-I-associated myelopathy/tropical spastic paraparesis - decrease in NK cell subset populations and activity in HTLV-I seropositive individuals

Feng Yu, Yasuto Itoyama, Kazuo Fujihara, Ikuo Goto

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We examined natural killer (NK) cell activity and NK cell subset populations in 18 patients with HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP), ten HTLV-I seropositive asymptomatic carriers and 20 seronegative healthy controls. The NK cell activity was significantly decreased in HAM/TSP, compared with that in controls. The percentages of NK cell subsets, such as CD16+, CD11b+, CD56+, CD16+CD56-, CD16-CD56+, CD16+CD8-, or CD16+CD3+ cells were significantly decreased in HAM/TSP patients. Of particular interest is that the percentage of CD16+CD3+ cells, which have a wide spectrum of cytotoxic properties commonly seen in NK, lymphokine activated killer (LAK) and antibody-dependent cellular-cytotoxic (ADCC) effector cells, was significantly decreased in HAM/TSP as compared to asymptomatic carriers as well as controls. The percentage of CD16+CD3+ cells correlated inversely with the value of spontaneous proliferation of peripheral blood lymphocytes (SPP), which is a characteristic change observed in HAM/TSP.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalJournal of Neuroimmunology
Volume33
Issue number2
DOIs
Publication statusPublished - 1991 Aug

Keywords

  • Human T lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
  • Lymphocyte subset
  • Monoclonal antibody
  • Natural killer cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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