Natural antibodies in sera from Japanese individuals infected with HTLV-I do not recognize HTLV-III

T. Hattori, M. Robert-Guroff, T. Chosa, M. Matsuoka, K. Yamaguchi, T. Ishii, R. C. Gallo, K. Takatsuki

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7 Citations (Scopus)

Abstract

Seventy-one sera from Japanese individuals infected with human T cell leukemia virus type I (HTLV-I) were examined for the presence of antibodies to HTLV-III by an enzyme-linked immunosorbent (ELISA) and by a strip radioimmunoassay based on the Western blot technique. The sera were from 23 healthy carriers and from 48 patients, including 18 with smoldering adult T cell leukemia (ATL), 13 with chronic ATL, and 17 with acute ATL. All people tested lived in the southwestern part of Japan, a known endemic area for HTLV-I infection. Antibodies against HTLV-I were detected in all sera both by indirect immunofluorescent methods and strip radioimmunoassay using cell lysates. Six sera were reactive in the ELISA assay for HTLV-III. But these sera did not react specifically to HTLV-III-related proteins (p15, p24, gp41) when analyzed by strip radioimmunoassay. Our data suggest that coincidental infection of HTLV-I and HTLV-III is quite rare in Japan.

Original languageEnglish
Pages (from-to)745-747
Number of pages3
JournalBlood
Volume66
Issue number3
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Hattori, T., Robert-Guroff, M., Chosa, T., Matsuoka, M., Yamaguchi, K., Ishii, T., Gallo, R. C., & Takatsuki, K. (1985). Natural antibodies in sera from Japanese individuals infected with HTLV-I do not recognize HTLV-III. Blood, 66(3), 745-747. https://doi.org/10.1182/blood.v66.3.745.745