TY - JOUR
T1 - NATRIURETIC EFFECT OF TMB‐8 IN ANAESTHETIZED DOGS
AU - Takahara, Akira
AU - Ogasawara, Aichi
AU - Suzuki‐Kusaba, Mizue
AU - Hisa, Hiroaki
AU - Satoh, Susumu
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/4
Y1 - 1991/4
N2 - 1. Effects of 8‐(N,N‐diethylamino)octyl‐3,4,5‐trimethoxybenzoate hydrochloride (TMB‐8), an inhibitor of intracellular calcium release, on renal function were examined in anaesthetized dogs. 2. Intrarenal arterial infusion of TMB‐8 (0.03 and 0.1 mg/kg per min) increased urine flow rate, urinary sodium excretion and fractional excretion of sodium without affecting blood pressure, renal blood flow or glomerular filtration rate. 3. The results suggest that TMB‐8 inhibits tubular sodium reabsorption to induce natriuresis.
AB - 1. Effects of 8‐(N,N‐diethylamino)octyl‐3,4,5‐trimethoxybenzoate hydrochloride (TMB‐8), an inhibitor of intracellular calcium release, on renal function were examined in anaesthetized dogs. 2. Intrarenal arterial infusion of TMB‐8 (0.03 and 0.1 mg/kg per min) increased urine flow rate, urinary sodium excretion and fractional excretion of sodium without affecting blood pressure, renal blood flow or glomerular filtration rate. 3. The results suggest that TMB‐8 inhibits tubular sodium reabsorption to induce natriuresis.
KW - TMB‐8
KW - kidney
KW - sodium excretion
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U2 - 10.1111/j.1440-1681.1991.tb01439.x
DO - 10.1111/j.1440-1681.1991.tb01439.x
M3 - Article
C2 - 2070567
AN - SCOPUS:0025905526
VL - 18
SP - 255
EP - 258
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
SN - 0305-1870
IS - 4
ER -