NATRIURETIC EFFECT OF TMB‐8 IN ANAESTHETIZED DOGS

Akira Takahara, Aichi Ogasawara, Mizue Suzuki‐Kusaba, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

1. Effects of 8‐(N,N‐diethylamino)octyl‐3,4,5‐trimethoxybenzoate hydrochloride (TMB‐8), an inhibitor of intracellular calcium release, on renal function were examined in anaesthetized dogs. 2. Intrarenal arterial infusion of TMB‐8 (0.03 and 0.1 mg/kg per min) increased urine flow rate, urinary sodium excretion and fractional excretion of sodium without affecting blood pressure, renal blood flow or glomerular filtration rate. 3. The results suggest that TMB‐8 inhibits tubular sodium reabsorption to induce natriuresis.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume18
Issue number4
DOIs
Publication statusPublished - 1991 Apr

Keywords

  • TMB‐8
  • kidney
  • sodium excretion

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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